5 Best NAD+ Supplements of 2025 [Full Comparison]
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The molecule Nicotinamide adenine dinucleotide, better known as NAD⁺, is one of the unsung heroes inside each of our cells. As a vital coenzyme, it plays a central role in converting nutrients into cellular energy, helping repair DNA damage, and supporting many of the processes linked to healthy aging. In other words, NAD⁺ isn’t just another supplement buzzword, it’s actually a biochemical linchpin.
Research shows that NAD⁺ levels naturally decline with age. For example, analyses of human tissue samples reveal decreases of 10%–25% in brain NAD⁺ between young adulthood and later life. Other studies note declines of 30% or more in liver tissue and other organs.
Supplementation with NAD⁺ precursors (such as nicotinamide riboside, NR, or nicotinamide mononucleotide, NMN) have been shown in human trials to safely increase NAD⁺ levels and raise related metabolites across multiple tissues. While human data on long-term functional effects remain limited, the early findings are promising and suggest NAD⁺‐boosting could be a meaningful part of a longevity strategy.
This guide compares the top NAD⁺ supplements. You’re likely to discover these brands as you’re researching the best options out there, so you can use this guide to compare their key product details (like third-party testing and dosage), pros, cons, and pricing. We’ll start the list of the best options with our own longevity product at Momentous, which supports NAD⁺.
1. Momentous Longevity
Key Things to Know About This Product
Third-Party Tested: Yes, NSF Certified for Sport
Money-Back Guarantee: Yes
Gluten Free: Yes
GMO Free: Yes
Vegan: Yes
Product Details:
Price: $69.95
Number of Servings: 30
Key ingredients: Niagen, NAC, PureQQ, Betaine, Vitamin C, B Vitamins
Serving Size: 3 capsules
Subscription: Yes - 25% discount on first order, 10% thereafter
Free shipping: Yes (orders over $75)
Pros:
NSF Certified for Sport
Comprehensive longevity formula rather than just a single-ingredient NAD+ booster
Solid subscription discount
Cons:
Price
Among the many NAD+ supplements available, Momentous Longevity stands out for its comprehensive, science-driven approach to healthy aging. Rather than focusing on a single ingredient, this formula combines six clinically studied bioactives: Niagen®, NAC, PureQQ®, Betaine, Vitamin C, and B Vitamins to support NAD+ production, cellular energy, protect DNA, and support brain and body resilience. It’s designed to go beyond NAD+ support and promote overall vitality and performance.
Customers report experiencing more consistent energy, sharper focus and cognitive function, and improved recovery over time. The inclusion of NSF Certified for Sport testing also sets Momentous apart. This certification ensures the product is free from contaminants and independently verified for purity and potency, offering peace of mind for athletes and everyday users alike.
With its emphasis on research-backed ingredients and meticulous quality control, Momentous Longevity positions itself as a premium choice. It’s true that this isn’t one of the cheapest NAD+ supplements on the market, but that reflects the brand’s commitment to sourcing, testing, and efficacy. For those who prioritize quality and long-term health outcomes over price, it’s a worthwhile investment.
Momentous Longevity is best suited for individuals focused on optimizing energy, recovery, and healthy aging—whether that’s athletes, high performers, or anyone looking to stay strong and sharp as they age. Overall, it offers one of the most complete longevity formulas available today.
2. Pure Encapsulations NR Longevity
Key Things to Know About This Product
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Third-Party Tested: No
Money-Back Guarantee: Yes
Gluten Free: Yes
GMO Free: Yes
Vegan: No, vegetarian
Product Details:
Price: $59.95
Number of Servings: 30
Key ingredients: Niagen, Broccoli Sprout Concentrate, Trans-Resveratrol
Serving Size: 2 capsules
Subscription: Yes, save 10%
Free shipping: Yes
Pros:
Competitive price
Strong customer ratings & reviews
Good subscription discount & free shipping
Cons:
No third-party testing
Pure Encapsulations NR Longevity is a well-regarded NAD⁺ support supplement that combines Niagen (Nicotinamide Riboside) with Broccoli Sprout Concentrate and Trans-Resveratrol. Designed to help boost cellular function and support healthy aging, it’s especially appealing for those looking for a cost-effective option that still delivers meaningful benefits.
While it isn’t third-party tested, the product comes with a money-back guarantee, which offers some reassurance to new users. It’s vegetarian-friendly, gluten-free, GMO-free, and suitable for most dietary needs, though it’s not fully vegan. Each bottle contains 30 servings at $59.95, with a subscription option that saves 10% and includes free shipping.
One of the standout aspects of NR Longevity is its strong customer ratings. Many users report noticeable improvements in fatigue, brain fog, mood, and even sleep quality after regular use. These positive experiences make it a compelling choice for anyone looking to enhance overall wellness while supporting NAD levels.
The serving size of two capsules is convenient, and the inclusion of synergistic antioxidants like trans-resveratrol adds value beyond NAD⁺ support alone. For those who want a reliable, reasonably priced supplement with proven customer satisfaction, Pure Encapsulations NR Longevity is a solid option.
3. Tru Niagen Pro
Key Things to Know About This Product
Third-Party Tested: Yes, NSF Certified for Sport
Money-Back Guarantee: Yes
Gluten Free: Yes
GMO Free: Yes
Vegan: No, vegetarian
Product Details:
Price: $116
Number of Servings: 30
Key ingredients: Niagen
Serving Size: 2 capsules
Subscription: Yes, save 20%
Free shipping: Yes, on all orders
Pros:
NSF Certified for Sport
Potent dose of Niagen (1,000 mg)
Backed by clinical research
Strong subscription discount and free shipping on all orders
Cons:
Cost
Only Niagen, no other ingredients
Tru Niagen is a widely recognized NAD⁺ supplement that uses Nicotinamide Riboside (NR) to support cellular energy, DNA repair, and healthy aging. It’s designed for individuals looking to maintain vitality, mental clarity, and overall cellular health as they age.
The product features a high dosage of NR (1000mg), which is double the amount in Momentous Longevity and more than three times the amount in Pure Encapsulation’s product. However, there are no other ingredients—it’s solely an NR supplement.
Tru Niagen is third-party tested and NSF Certified for Sport, which provides peace of mind for users who prioritize purity and quality. It is vegetarian, non-GMO, and free from common allergens, making it suitable for a wide range of dietary preferences.
Many users give Tru Niagen high ratings, often citing noticeable improvements in energy, muscle recovery, mood, insulin sensitivity, and cognitive focus after consistent use with no reported side effects. These reports highlight its potential benefits for both busy professionals and active individuals seeking better recovery and daily performance.
At $116 for 30 servings, it is an expensive option and not for those looking for cost-effective longevity formulas. That said, data from clinical trials, independent testing, and strong customer satisfaction makes Tru Niagen a standout in the NR supplements category for those with the means to pay for it.
4. Elysium Basis
Key Things to Know About This Product
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Third-Party Tested: Yes, NSF Certified for Sport
Money-Back Guarantee: Yes
Gluten Free: Yes
GMO Free: Yes
Vegan: Yes
Product Details:
Price: $65
Number of Servings: 30
Key ingredients: Nicotinamide Riboside (NR), Pterostilbene
Serving Size: 2 capsules
Subscription: Yes - monthly or annual subscription discounts
Free shipping: Yes, on all orders
Pros:
NSF Certified for Sport certification
Strong subscription discounts & free shipping
Competitively priced
Developed by a longevity doctor
Cons:
No customer ratings or reviews
Elysium Basis is one of the most recognized NAD⁺ supplements on the market, developed by leading scientists in the field of longevity research. Its formula combines Nicotinamide Riboside (NR) and Pterostilbene, two clinically studied ingredients shown to boost NAD⁺ levels, support cellular energy, and slow the aging process.
One of the standout features of Basis is its NSF Certified for Sport certification, a gold standard in supplement quality and safety. This ensures that every batch is independently tested and verified to be free from contaminants, making it a trusted choice for athletes and health-conscious users alike. The supplement is also vegan, gluten-free, non-GMO, and comes with a money-back guarantee, adding to its credibility and appeal.
At $65 for 30 servings, Basis is competitively priced for a longevity supplement, especially given its third-party testing and scientific pedigree. Customers can also take advantage of subscription discounts and free shipping on all orders.
The only drawback is the lack of published customer ratings and reviews. Still, for those seeking a research-backed, rigorously tested NAD⁺ supplement developed by longevity experts, Elysium Basis stands out as a premium and trustworthy option.
5. Thorne NiaCel 400
Key Things to Know About This Product
Third-Party Tested: Yes, NSF Certified for Sport
Money-Back Guarantee: Yes
Gluten Free: Yes
GMO Free: Yes
Vegan: Yes
Product Details:
Price: $70
Number of Servings: 60
Key ingredients: Nicotinamide Riboside (NR) Hydrogen Malate, Betaine
Serving Size: 1 capsule
Subscription: Yes, save 20%
Free shipping: Yes, on all orders
Pros:
NSF Certified for Sport
Cost effective
Strong subscription discount & free shipping
Good customer reviews & ratings
Uses NR HM, which is well absorbed
Cons:
Just two ingredients, not a comprehensive formula
Thorne NiaCel 400 is a clean, science-backed NAD⁺ supplement that delivers a focused and effective approach to supporting cellular energy and healthy aging. Its formula centers on Nicotinamide Riboside (NR) Hydrogen Malate, a highly absorbable form of NR that helps boost NAD⁺ levels to support energy metabolism, DNA repair, and overall vitality.
Thorne’s commitment to quality is evident: NiaCel 400 is NSF Certified for Sport, meaning it’s independently tested for purity and contaminants. The supplement is also vegan, gluten-free, and non-GMO, making it suitable for nearly all users. Each bottle provides 60 servings for $70 making it the most competitively priced longevity supplement reviewed here. With a 20% subscription discount and free shipping, it’s certainly a cost-effective option for long-term use.
Customers consistently rate NiaCel 400 highly, often noting improved energy, inflammation, mental clarity, and workout recovery. Many appreciate that it’s a simple, no-frills product that focuses on what works: quality ingredients and proven efficacy with strong bioavailability.
The only limitation is that it’s a streamlined formula with just two key ingredients, so those looking for a more comprehensive longevity product might prefer something that includes a broader formula. Still, for anyone seeking a pure, well-absorbed NAD⁺ booster from a trusted brand, Thorne NiaCel 400 is a standout choice.
