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Apigenin is a bioflavonoid compound found in various fruits, vegetables, and herbs, such as chamomile and parsley, which can help reduce stress and promote higher-quality sleep. Apigenin works by activating chloride ion channels, calming overall neuronal activity in the forebrain, and allowing the body to enter a more restful state. Research has also demonstrated that taking an apigenin supplement can decrease the stress hormone cortisol.

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Several plant bioactive compounds have exhibited functional activities that suggest they could play a remarkable role in preventing a wide range of chronic diseases. The largest group of naturally-occurring polyphenols are the flavonoids, including apigenin. Higher dietary intake of certain polyphenols may be associated with better sleep quality among adults. Additionally, studies have shown that apigenin increases total sleep duration as well as quickens sleep latency.

Apigenin capsule


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Protocol Integration

Take daily
30-60 minutes prior to bedtime

Clinical Research

Apigenin has been extensively studied, and emerging research supports its potential benefits. Studies have shown that apigenin activates chloride ion channels, promoting restful sleep and faster sleep onset. Research has also indicated that apigenin can decrease cortisol levels, contributing to stress reduction and relaxation. Numerous other studies have investigated its effects on cognitive function, stress reduction, and overall health. These studies suggest that apigenin can enhance memory, improve learning ability, reduce anxiety and depression-like behaviors, and provide antioxidant and anti-inflammatory effects. However, further research is ongoing to fully understand its mechanisms of action and potential applications.

Expert Verified
Dr. Andrew Huberman Dr. Andrew Huberman

From Dr. Andrew Huberman, host of the Huberman Lab podcast

"There's another supplement that could be quite useful, which is Apigenin, which is a derivative of chamomile, 50 milligrams of apigenin can augment or support sleepiness to help fall asleep and stay asleep."

What to Expect With Apigenin

When to Use
1 x capsule 30-60 minutes prior to sleep
Onset Time
2-4 days
Results may vary, but many individuals typically experience benefits within a few days of regular use, while others may require longer to see significant changes.
Expected Results
Sleep Cognitive Function
Apigenin can be used as a daily supplement to support cognitive function and manage stress. Results may vary depending on individual factors such as age, lifestyle, and overall health.

Apigenin Supplement Facts

Apigenin Supplement Facts

Frequently Asked Questions

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